解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:STUDY OBJECTIVE:To evaluate the effectiveness and safety of enoxaparin therapy in a neonatal intensive care unit (NICU). DESIGN:Retrospective chart review. SETTING:Level III NICU in a Canadian academic center. PATIENTS:All neonates treated with enoxaparin while in the NICU between January 1, 1998, and June 1, 2006. ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.9.1263
更新日期:2007-09-01 00:00:00
abstract::Hospital pharmacists are often consulted for their knowledge about coagulation and therapeutic interventions for the management of critical bleeding. Many pharmacotherapies are available for this purpose, both systemic and topical, and others are in development. These agents and their mechanisms of action are reviewed...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.27.9part2.69S
更新日期:2007-09-01 00:00:00
abstract:STUDY OBJECTIVES:To examine glycosylated hemoglobin (A1C) values longitudinally in patients who newly started metformin, sulfonylurea, or thiazolidinedione monotherapy; in a subset of patients whose A1C values were 7% or greater before starting therapy (baseline) and who achieved A1C goal (A1C < 7%) during therapy, rat...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.8.1102
更新日期:2007-08-01 00:00:00
abstract::Methemoglobin, a form of hemoglobin that does not bind oxygen, is produced when iron in red blood cells is oxidized from the ferrous state to the ferric state. Methemoglobinemia develops in the presence of oxidizing agents, such as benzocaine-containing topical anesthetic sprays, and it is characterized by cyanosis. I...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.8.1206
更新日期:2007-08-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate claims-related treatment adherence, health care resource utilization, and associated costs of therapy conversion from an insulin vial and syringe to a premixed biphasic insulin analog pen device among privately insured patients with type 2 diabetes mellitus. DESIGN:Retrospective, longitudin...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.7.948
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:As one of the most accessible health care professionals, pharmacists are in an ideal position to provide tobacco-cessation and prevention services. Although there is growing interest in expanding the pharmacist's role in tobacco treatment, few published studies have assessed the efficacy or effectiveness of ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.27.7.1040
更新日期:2007-07-01 00:00:00
abstract:STUDY OBJECTIVES:To determine changes in bone mineral density (BMD) and T scores of patients after 2 years of teriparatide therapy, and to determine the number of fractures that occurred during therapy. DESIGN:Prospective, observational study. SETTING:Pharmacist-run teriparatide clinic in a private-practice endocrino...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:10.1592/phco.27.6.779
更新日期:2007-06-01 00:00:00
abstract::Beta-blockers are an important cardiovascular drug class, recommended as first-line treatment of numerous diseases such as heart failure, hypertension, and angina, as well as treatment after myocardial infarction. However, responses to a beta-blocker are variable among patients. Results of numerous studies now suggest...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.27.6.874
更新日期:2007-06-01 00:00:00
abstract:STUDY OBJECTIVES:To evaluate the efficacy of a single, low-dose injection of botulinum toxin type A in relieving pain in Korean patients with piriformis syndrome resistant to conventional therapy, and to assess the drug's influence on these patients' quality of life. DESIGN:Prospective, single-site, open-label trial. ...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:10.1592/phco.27.5.657
更新日期:2007-05-01 00:00:00
abstract::Fentanyl iontophoretic transdermal system (ITS) is a novel, patient-activated drug delivery device used for the management of acute postoperative pain in the hospital setting. This credit-card-sized device uses an imperceptible current of 170 milliampere to actively deliver a fentanyl hydrochloride 40-microg dose into...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.27.5.745
更新日期:2007-05-01 00:00:00
abstract::Several pivotal clinical trials have generated new knowledge regarding drug therapy for heart failure. Thus, the Heart Failure Society of America (HFSA) and the American College of Cardiology-American Heart Association (ACC-AHA) guidelines were updated in 2006 and 2005, respectively. We review the evidence from these ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.27.4part2.12S
更新日期:2007-04-01 00:00:00
abstract:STUDY OBJECTIVE:To compare the effectiveness of darbepoetin alfa with epoetin alfa (recombinant human erythropoietin [rHuEPO]) for achieving transfusion independence and increasing hemoglobin concentrations in critically ill patients. DESIGN:Retrospective, descriptive study. SETTING:Level I trauma center intensive ca...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:10.1592/phco.27.4.535
更新日期:2007-04-01 00:00:00
abstract::A 67-year-old woman with iron deficiency anemia required parenteral iron therapy and was treated with intravenous ferric gluconate. She tolerated the first dose, but after the second dose, she developed a tingling feeling all over her body, along with swelling in her hands and feet, and a rash with hives over most of ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.4.613
更新日期:2007-04-01 00:00:00
abstract::Midazolam is a commonly used sedative in critically ill, mechanically ventilated patients in intensive care unit (ICU) settings worldwide. We used a nine-step decision-making algorithm to determine whether therapeutic monitoring of midazolam in the ICU is warranted. Midazolam has a higher clearance and shorter half-li...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.27.3.389
更新日期:2007-03-01 00:00:00
abstract::Serious gram-positive infections present an increasingly common therapeutic dilemma. Combination antimicrobial regimens (e.g., linezolid with rifampin) aimed at improving bacterial eradication and preventing resistance are often used; however, most data supporting this treatment strategy are not from randomized contro...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.3.476
更新日期:2007-03-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the disposition of pentoxifylline and its metabolite, lisofylline, in New Zealand rabbits after two alternative routes of administration, intranasal and intratracheal. DESIGN:Pharmacokinetics study in an animal model. SETTING:University-affiliated animal care facility. SUBJECTS:Twenty New...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.2.200
更新日期:2007-02-01 00:00:00
abstract::A 58-year-old man went to his physician with complaints of midepigastric pain, flatulence, belching, and shortness of breath. During a physical examination, the patient was in no acute distress. The patient underwent an ultrasound examination, which revealed cholelithiasis, a laparoscopic cholecystectomy, which reveal...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.2.299
更新日期:2007-02-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the level of agreement between two sets of criteria, the Thrombolysis in Myocardial Infarction (TIMI) criteria and investigator-developed criteria, for identifying bleeding events in patients who had undergone a percutaneous coronary intervention (PCI) and to measure length of hospital stay ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.1.36
更新日期:2007-01-01 00:00:00
abstract::A 71-year-old Caucasian woman was admitted to the hospital with right-sided weakness and slurred speech. Glioblastoma multiforme was diagnosed, and resection of the tumor was performed. During the patient's hospitalization, blood and urine cultures were obtained after her temperature rose to 103.3 degrees F. Four bloo...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.1.161
更新日期:2007-01-01 00:00:00
abstract:STUDY OBJECTIVES:To determine the frequency and type of complementary and alternative medicine (CAM) use among healthy volunteers participating in research, and to investigate the potential for interactions between commonly used CAM modalities and various drugs. DESIGN:Prospective evaluation. SETTING:University gener...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.12.1794
更新日期:2006-12-01 00:00:00
abstract::The prevalence of cardiovascular risk factors continues to rise, with considerable emphasis on the upward trends in obesity and diabetes mellitus, which have increased by 46% and 60%, respectively, in the past 10 years. The alarming increase in the prevalence of diabetes and obesity has resulted in the development of ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.12part2.227S
更新日期:2006-12-01 00:00:00
abstract:STUDY OBJECTIVES:To examine potential threats to internal and external study validity caused by differential patient withdrawal from a randomized controlled trial evaluating pharmacist management of hypertension, to compare the characteristics of patients who withdrew with those of patients who completed the study, and...
journal_title:Pharmacotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1592/phco.26.11.1565
更新日期:2006-11-01 00:00:00
abstract::A 37-year-old Hispanic man with advanced acquired immunodeficiency syndrome developed extensive pulmonary disease with persistent cough, fever, night sweats, worsening dyspnea, and weight loss. Sputum samples showed scant growth of acid-fast bacilli. He failed to respond to the standard tuberculosis regimen of isoniaz...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.11.1646
更新日期:2006-11-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the number of women who have menopausal symptoms after discontinuing hormone therapy, to determine how many of these women subsequently require nonhormonal alternatives to manage their symptoms, and to assess the effectiveness of those therapies. DESIGN:One-year retrospective study. SETTI...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.10.1403
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVES:To explore the illicit use of specific prescription stimulants among college students and add to our understanding of reasons (motives) and routes of administration associated with illicit use of these drugs. METHODS:A random sample of 4580 college students self-administered a Web-based survey. The survey c...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.10.1501
更新日期:2006-10-01 00:00:00
abstract::Nausea and vomiting, common symptoms during pregnancy, often are regarded as an unpleasant but normal part of pregnancy during the first and early second trimesters. Nausea and vomiting of pregnancy (NVP) occurs in approximately 75-80% of pregnant women. The exact etiology and pathogenesis of NVP are poorly understood...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.26.9.1273
更新日期:2006-09-01 00:00:00
abstract::Methamphetamine is a highly potent and addictive drug that is abused in the United States and around the world. The drug is inexpensive and easily manufactured from simple chemicals such as pseudoephedrine. These features, coupled with its long half-life and highly addictive nature, contribute to the increasing proble...
journal_title:Pharmacotherapy
pub_type: 历史文章,杂志文章,评审
doi:10.1592/phco.26.8.1148
更新日期:2006-08-01 00:00:00
abstract::A 53-year-old woman with an intraabdominal infection secondary to Candida albicans experienced hyperbilirubinemia after receiving amphotericin B in two different formulations--amphotericin B deoxycholate and amphotericin B lipid complex. Only a few case reports of amphotericin B-induced hyperbilirubinemia have been do...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.7.1011
更新日期:2006-07-01 00:00:00
abstract:STUDY OBJECTIVE:To compare the efficacy of amlodipine and valsartan in African-American patients with hypertension using ambulatory blood pressure monitoring (ABPM). DESIGN:Prospective, randomized, double-blind, crossover comparison study. SETTING:University-affiliated cardiac center clinic. PATIENTS:Twenty African-...
journal_title:Pharmacotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1592/phco.26.7.889
更新日期:2006-07-01 00:00:00
abstract:STUDY OBJECTIVE:To investigate the relationship between two widely used, generic health-related quality of life (HRQOL) measures, Short Form-12 (SF-12) and EuroQol's EQ-5D, and potentially inappropriate drug use in an elderly cohort. DESIGN:Longitudinal retrospective cohort study. DATA SOURCE:Medical Expenditure Pane...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.6.768
更新日期:2006-06-01 00:00:00
abstract::A 58-year-old woman who had been taking digoxin 0.25 mg/day for more than 35 years for heart palpitations after mitral valve repair was prescribed a 5-day course of telithromycin for acute bronchitis. On the sixth day of therapy, she came to the emergency department complaining of general malaise and having experience...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.6.872
更新日期:2006-06-01 00:00:00
abstract:STUDY OBJECTIVE:To perform a cost-effectiveness analysis comparing three treatment approaches during nonurgent percutaneous coronary intervention (PCI): bivalirudin with provisional glycoprotein (GP) IIb-IIIa inhibitor therapy, unfractionated heparin (UFH) with eptifibatide, and UFH with abciximab. DESIGN:Literature-b...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.5.609
更新日期:2006-05-01 00:00:00
abstract::Daptomycin is a lipopeptide antibiotic active against multidrug-resistant gram-positive organisms. Our search of the literature found no published pediatric pharmacokinetic data. We report the use of pharmacokinetic analysis of daptomycin in a 13-year-old boy with vancomycin-resistant Enterococcus faecium endocarditis...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.5.694
更新日期:2006-05-01 00:00:00
abstract::The effects of proton pump inhibitors on the pharmacokinetics of atazanavir and amprenavir (administered as fosamprenavir) were rigorously evaluated in healthy volunteers in two studies, but formal studies in persons infected with human immunodeficiency virus (HIV) are lacking. We describe a 65-year-old man with HIV w...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.4.511
更新日期:2006-04-01 00:00:00
abstract::An 87-year-old African-American man came to the internal medicine clinic for a routine anticoagulation management visit. He had no complaints. His medical history was significant for stage IV-A follicular non-Hodgkin's lymphoma, atrial fibrillation, and hypertension. His long-term drug therapy consisted of warfarin, f...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.4.583
更新日期:2006-04-01 00:00:00
abstract::A formerly infrequently isolated strain of Clostridium difficile known as BI/NAP1 has resulted in geographically diverse outbreaks of C. difficile-associated disease. Such rapid dissemination and distribution of an outbreak strain of C. difficile are unprecedented, with many regions across North America, as well as se...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.26.3.299
更新日期:2006-03-01 00:00:00
abstract::Ziconotide intrathecal infusion was recently approved by the United States Food and Drug Administration for the treatment of intractable severe chronic pain. Patients with neuropathic pain make up a significant population among those who experience chronic pain for which there are less than optimal pharmacotherapeutic...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:10.1592/phco.26.3.395
更新日期:2006-03-01 00:00:00
abstract:STUDY OBJECTIVE:To develop and evaluate a peer review group (PRG) meeting using feedback data on a patient level to improve the quality of drug therapy for prevention of recurrent myocardial infarction. DESIGN:Prospective follow-up study. DATA SOURCE:General practitioners' computerized patients records (intervention ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.2.254
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:To review the current pharmacotherapy for idiopathic pulmonary arterial hypertension (IPAH). METHODS:A search of the primary literature was conducted by using MEDLINE, the National Institutes of Health medical research Web site (www.clinicaltrials.gov), and the United States Food and Drug Administration's Ce...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.2006.26.1.68
更新日期:2006-01-01 00:00:00
abstract::Clinical outcomes that measure how patients feel, function, or survive are the most important and relevant outcomes of therapy in clinical trials and in clinical practice. Surrogate end points, which do not directly measure clinical benefit to the patient, may function as substitutes for clinical end points in clinica...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.2005.25.12part2.109S
更新日期:2005-12-01 00:00:00